The tissue specific regulation of miR22 expression in the lung and brain by ribosomal protein L29.

ABSTRACT: Endogenous miR22 is associated with a diverse range of biological processes through post-translational modification of gene expression and its deregulation results in various diseases including cancer. Its expression is usually tissue or cell-specific, however, the reasons behind this tissue or cell specificity are not clearly outlined till-date. Therefore, our keen interest was to investigate the mechanisms of tissue or cell-specific expression of miR22. In the current study, miR22 expression showed a tissues-specific difference in the poly(I:C) induced inflammatory mouse lung and brain tissues. The cell-specific different expression of miR22 was also observed in inflammatory glial cells and endothelial cells. The pattern of RPL29 expression was also similar to miR22 in these tissues and

SUBMITTER: Ali MI 

PROVIDER: S-EPMC7530758 | biostudies-literature | 2020 Oct

REPOSITORIES: biostudies-literature