Quantile-dependent heritability of computed tomography, dual-energy x-ray absorptiometry, anthropometric, and bioelectrical measures of adiposity.

ABSTRACT:

Background/objectives

Quantile-dependent expressivity occurs when a gene's phenotypic expression depends upon whether the trait (e.g., BMI) is high or low relative to its distribution. We have previously shown that the obesity effects of a genetic risk score (GRS_BMI) increased significantly with increasing quantiles of BMI. However, BMI is an inexact adiposity measure and GRS_BMI explains <3% of the BMI variance. The purpose of this paper is to test BMI for quantile-dependent expressivity using a more inclusive genetic measure (h², heritability in the narrow sense), extend the result to other adiposity measures, and demonstrate its consistency with purported gene-environment interactions.

Subjects/methods

Quantile-specific offspring-parent reg

SUBMITTER: Williams PT 

PROVIDER: S-EPMC7530941 | biostudies-literature | 2020 Oct

REPOSITORIES: biostudies-literature