Antiviral activity of digoxin and ouabain against SARS-CoV-2 infection and its implication for COVID-19.

ABSTRACT: The current coronavirus (COVID-19) pandemic is exacerbated by the absence of effective therapeutic agents. Notably, patients with COVID-19 and comorbidities such as hypertension and cardiac diseases have a higher mortality rate. An efficient strategy in response to this issue is repurposing drugs with antiviral activity for therapeutic effect. Digoxin (DIG) and ouabain (OUA) are FDA drugs for heart diseases that have antiviral activity against several coronaviruses. Thus, we aimed to assess antiviral activity of DIG and OUA against SARS-CoV-2 infection. The half-maximal inhibitory concentrations (IC₅₀) of DIG and OUA were determined at a nanomolar concentration. Progeny virus titers of single-dose treatment of DIG, OUA and remdesivir were approximately 10³-, 10^4<

SUBMITTER: Cho J 

PROVIDER: S-EPMC7530981 | biostudies-literature | 2020 Oct

REPOSITORIES: biostudies-literature