Supplementation with antithrombin III ex vivo optimizes enoxaparin responses in critically injured patients.

ABSTRACT:

Background

The high incidence of venous thromboembolism (VTE) following trauma persists in spite of aggressive thromboprophylaxis strategies. Approximately half of VTE patients do not achieve the recommended anti-FXa response to enoxaparin anticoagulation (0.1-0.4 IU/mL), however, research to explain or correct this phenomenon is lacking. We hypothesized that antithrombin III (AT) deficiency is associated with poor enoxaparin responsiveness in trauma patients that develop VTE which can be reversed through supplementation with AT.

Methods and findings

A retrospective cohort study was performed on plasma collected from trauma patients who did and did not develop pulmonary embolism (PE) as well as healthy volunteers. AT levels, thrombin generation, and anti-FXa levels were meas

SUBMITTER: Cardenas JC 

PROVIDER: S-EPMC7531030 | biostudies-literature | 2020 Mar

REPOSITORIES: biostudies-literature