Antibiotic prophylaxis in breast cancer surgery. A randomized controlled trial.

ABSTRACT:

Purpose

To assess the effect of antibiotic prophylaxis on surgical site infection (SSI) rates in women undergoing breast cancer surgery in two tertiary hospitals in Brazil.

Methods

This was a randomized, double-blind, placebo-controlled, parallel-group clinical trial. A total of 124 women without independent risk factors for SSI were randomly assigned to receive either cefazolin (antibiotic group, n = 62) or placebo (control group, n = 62) as preoperative prophylaxis. After surgery, all surgical wounds were examined once a week, for four weeks, according to the Centers for Disease Control and Prevention definitions and classifications for SSI.

Results

Baseline characteristics were homogeneous between the two groups. Only one patient in the antibiotic group developed S

SUBMITTER: Prudencio RMA 

PROVIDER: S-EPMC7531055 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature