The prevalence and mechanism of triclosan resistance in Escherichia coli isolated from urine samples in Wenzhou, China.

ABSTRACT:

Background

The widespread application of triclosan contributes to its residual deposition in urine, which provides an environment of long-term exposure to triclosan for the intestinal Escherichia coli. We determined the triclosan and antibiotic resistance characteristics of E. coli strains isolated from urine samples and further investigated the resistance mechanism and molecular epidemic characteristics of triclosan-resistant E. coli isolates.

Methods

A total of 200 non-repetitive E. coli strains were isolated from urine samples and then identified. The minimum inhibitory concentrations (MICs) of triclosan and antibiotics, fabI mutation, efflux pump activity, the expression of 14 efflux pump encoding genes, and epidemiological characteristics were determined by the agar dil

SUBMITTER: Zeng W 

PROVIDER: S-EPMC7531082 | biostudies-literature | 2020 Oct

REPOSITORIES: biostudies-literature