The fraction of sensitization among lung transplant recipients in a transplant center in Japan.

ABSTRACT:

Background

Anti-human leukocyte antigen (HLA) antibody testing was approved by the Japanese government in 2018. As such, there was no longitudinal data regarding the HLA-sensitization of lung transplant (LTX) patients in Japan. We therefore set out to measure anti-HLA antibodies from all our LTX patients during their annual follow-up to characterize the sensitization status in the Japanese population.

Methods

The cross-sectional study was conducted for consecutive LTX recipients who underwent transplantation from January 2000 to January 2020 at Tohoku University Hospital (TUH). The serum from the recipients was screened for anti-HLA antibody with the panel-reactive assay (PRA) and the donor-specific antibodies (DSA).

Results

Sensitization was reviewed in 93 LTX recipi

SUBMITTER: Kumata S 

PROVIDER: S-EPMC7531146 | biostudies-literature | 2020 Oct

REPOSITORIES: biostudies-literature