Biomarkers of environmental manganese exposure and associations with childhood neurodevelopment: a systematic review and meta-analysis.

ABSTRACT:

Background

Although prior studies showed a correlation between environmental manganese (Mn) exposure and neurodevelopmental disorders in children, the results have been inconclusive. There has yet been no consistent biomarker of environmental Mn exposure. Here, we summarized studies that investigated associations between manganese in biomarkers and childhood neurodevelopment and suggest a reliable biomarker.

Methods

We searched PubMed and Web of Science for potentially relevant articles published until December 31th 2019 in English. We also conducted a meta-analysis to quantify the effects of manganese exposure on Intelligence Quotient (IQ) and the correlations of manganese in different indicators.

Results

Of 1754 citations identified, 55 studies with 13,388 subjects

SUBMITTER: Liu W 

PROVIDER: S-EPMC7531154 | biostudies-literature | 2020 Oct

REPOSITORIES: biostudies-literature