Amorphous silica nanoparticles accelerated atherosclerotic lesion progression in ApoE^-/- mice through endoplasmic reticulum stress-mediated CD36 up-regulation in macrophage.

ABSTRACT:

Background

The biosafety concern of silica nanoparticles (SiNPs) is rapidly expanding alongside with its mass production and extensive applications. The cardiovascular effects of SiNPs exposure have been gradually confirmed, however, the interaction between SiNPs exposure and atherosclerosis, and the underlying mechanisms still remain unknown. Thereby, this study aimed to explore the effects of SiNPs on the progression of atherosclerosis, and to investigate related mechanisms.

Results

We firstly investigated the in vivo effects of SiNPs exposure on atherosclerosis via intratracheal instillation of ApoE^-/- mice fed a Western diet. Ultrasound microscopy showed a significant increase of pulse wave velocity (PWV) compared to the control group, and the histopathologica

SUBMITTER: Ma R 

PROVIDER: S-EPMC7531166 | biostudies-literature | 2020 Oct

REPOSITORIES: biostudies-literature