The role of TRPV1 ion channels in the suppression of gastric cancer development.

ABSTRACT:

Background

Although the aberrant expression and function of most Ca²⁺-permeable channels are known to promote gastrointestinal tumors, the association between transient receptor potential vanilloid receptor 1 (TRPV1) channels and gastric cancer (GC) has not yet been explored. Herein, we sought to determine the role of TRPV1 channels in the development of GC and to elucidate the underlying molecular mechanisms involved therein.

Methods

Immunohistochemistry, qPCR, Western blot, immunofluorescence assays were used to detect the mRNA and protein expression of TRPV1 in GC cells and tissues, and the clinical significance of TRPV1 in GC was also studied by clinicopathologic analysis. CCK8, colony formation, flow cytometry assays were used to detect the proliferation and

SUBMITTER: Gao N 

PROVIDER: S-EPMC7531167 | biostudies-literature | 2020 Oct

REPOSITORIES: biostudies-literature