C3: connect separate connected components to form a succinct disease module.

ABSTRACT:

Background

Precise disease module is conducive to understanding the molecular mechanism of disease causation and identifying drug targets. However, due to the fragmentization of disease module in incomplete human interactome, how to determine connectivity pattern and detect a complete neighbourhood of disease based on this is still an open question.

Results

In this paper, we perform exploratory analysis leading to an important observation that through a few intermediate nodes, most separate connected components formed by disease-associated proteins can be effectively connected and eventually form a complete disease module. And based on the topological properties of these intermediate nodes, we propose a connect separate connected components (C3) method to detect a succinct d

SUBMITTER: Wang B 

PROVIDER: S-EPMC7531168 | biostudies-literature | 2020 Oct

REPOSITORIES: biostudies-literature