Significance of Tumor Mutation Burden in Immune Infiltration and Prognosis in Cutaneous Melanoma.

ABSTRACT: Background: Melanoma is highly immunogenic and therefore suitable for immunotherapy, but the efficacy is limited by response rate. In several types of tumor, tumor mutation burden (TMB) and immune infiltration have been reported to predict the response to immunotherapy, although each has its limitations. In the current study, we aimed to explore the association of TMB with immune infiltration and prognosis in cutaneous melanoma. Methods: The data of cutaneous melanoma used for analyses was downloaded from The Cancer Genome Atlas (TCGA) database. The mutation data was sorted using "maftools" R package. TMB was estimated and then patients were divided into two groups based on TMB. The association of TMB with prognosis and clinical characteristics was explored. Differential anal

SUBMITTER: Kang K 

PROVIDER: S-EPMC7531222 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature