Microfluidic-prepared, monodisperse, X-ray-visible, embolic microspheres for non-oncological embolization applications.

ABSTRACT: Embolotherapy using particle embolics is normally performed with exogenous contrast to assist in visualization. However, the exact location of the embolics cannot be identified after contrast washout. We developed a novel, pseudo-check valve-integrated microfluidic device, that partitions barium- impregnated alginate from crosslinking solution, thereby preventing nozzle failure. This enables rapid and continuous generation of inherently X-ray-visible embolic microspheres (XEMs) with uniform size. The XEMs are visible under clinical X-ray and cone beam CT both in vitro and in vivo. In particular, we demonstrated the embolization properties of these XEMs in large animals, performing direct intra- and post-procedural assessment of embolic delivery. The persistent radiopacity of these XEMs ena

SUBMITTER: Beh CW 

PROVIDER: S-EPMC7531348 | biostudies-literature | 2020 Oct

REPOSITORIES: biostudies-literature