Loss of inner kinetochore genes is associated with the transition to an unconventional point centromere in budding yeast.

ABSTRACT:

Background

The genomic sequences of centromeres, as well as the set of proteins that recognize and interact with centromeres, are known to quickly diverge between lineages potentially contributing to post-zygotic reproductive isolation. However, the actual sequence of events and processes involved in the divergence of the kinetochore machinery is not known. The patterns of gene loss that occur during evolution concomitant with phenotypic changes have been used to understand the timing and order of molecular changes.

Methods

I screened the high-quality genomes of twenty budding yeast species for the presence of well-studied kinetochore genes. Based on the conserved gene order and complete genome assemblies, I identified gene loss events. Subsequently, I searched the intergeni

SUBMITTER: Vijay N 

PROVIDER: S-EPMC7531349 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature