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Ig-like ACE2 protein therapeutics: A revival in development during the COVID-19 pandemic.

ABSTRACT: While the potential therapeutic utility of angiotensin-converting enzyme 2 (ACE2) is well established, the clinical development of ACE2 drugs has been limited, likely due in part to the short half-life of the protein. In contrast, Ig-like ACE2 fusion proteins have exhibited greatly extended plasma half-life in vivo, and they have been shown to have a potent neutralization effect against SARS-CoV-2. Clinical investigation of Ig-like ACE2 fusion proteins as COVID-19 interventions is thus warranted.

SUBMITTER: Qian K

PROVIDER: S-EPMC7531491 | biostudies-literature | 2020 Jan-Dec

REPOSITORIES: biostudies-literature

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Ig-like ACE2 protein therapeutics: A revival in development during the COVID-19 pandemic.

Qian Kewen K Hu Shi S

mAbs 20200101 1

While the potential therapeutic utility of angiotensin-converting enzyme 2 (ACE2) is well established, the clinical development of ACE2 drugs has been limited, likely due in part to the short half-life of the protein. In contrast, Ig-like ACE2 fusion proteins have exhibited greatly extended plasma half-life in vivo, and they have been shown to have a potent neutralization effect against SARS-CoV-2. Clinical investigation of Ig-like ACE2 fusion proteins as COVID-19 interventions is thus warranted ...[more]

PMID: 32546047

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