A Human Depression Circuit Derived From Focal Brain Lesions.

ABSTRACT:

Background

Focal brain lesions can lend insight into the causal neuroanatomical substrate of depression in the human brain. However, studies of lesion location have led to inconsistent results.

Methods

Five independent datasets with different lesion etiologies and measures of postlesion depression were collated (N = 461). Each 3-dimensional lesion location was mapped to a common brain atlas. We used voxel lesion symptom mapping to test for associations between depression and lesion locations. Next, we computed the network of regions functionally connected to each lesion location using a large normative connectome dataset (N = 1000). We used these lesion network maps to test for associations between depression and connected brain circuits. Reproducibility was assessed using a

SUBMITTER: Padmanabhan JL 

PROVIDER: S-EPMC7531583 | biostudies-literature | 2019 Nov

REPOSITORIES: biostudies-literature