Eosinophils Mediate Tissue Injury in the Autoimmune Skin Disease Bullous Pemphigoid.

ABSTRACT: Eosinophils are typically associated with unique inflammatory settings, including allergic inflammation and helminth infections. However, new information suggests that eosinophils contribute more broadly to inflammatory responses and participate in local immune regulation and the tissue remodeling/repair events linked with a variety of diseases. Eosinophilic infiltration has long been a histologic hallmark of bullous pemphigoid (BP), a subepidermal autoimmune blistering disease characterized by autoantibodies directed against basement membrane protein BP180. However, the exact role of eosinophils in disease pathogenesis remains largely unknown. We show here that eosinophils are necessary for IgE autoantibody-mediated BP blister formation in a humanized IgE receptor mouse model of BP. Disea

SUBMITTER: Lin L 

PROVIDER: S-EPMC7531612 | biostudies-literature | 2018 May

REPOSITORIES: biostudies-literature