Mechanistic Insights Into the Anticancer Properties of the Auranofin Analog Au(PEt₃)I: A Theoretical and Experimental Study.

ABSTRACT: Au(PEt₃)I (AF-I hereafter), the iodide analog of the FDA-approved drug auranofin (AF hereafter), is a promising anticancer agent that produces its pharmacological effects through interaction with non-genomic targets such as the thioredoxin reductase system. AF-I is endowed with a very favorable biochemical profile showing potent in vitro cytotoxic activity against several cancer types including ovarian and colorectal cancer. Remarkably, in a recent publication, some of us reported that AF-I induces an almost complete and rapid remission in an orthotopic in vivo mouse model of ovarian cancer. The cytotoxic potency does not bring about highly severe side effects, making AF-I very well-tolerated even for higher doses, even more so than the pharmacologically active one

SUBMITTER: Tolbatov I 

PROVIDER: S-EPMC7531625 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature