Non-equilibrium landscape and flux reveal the stability-flexibility-energy tradeoff in working memory.

ABSTRACT: Uncovering the underlying biophysical principles of emergent collective computational abilities, such as working memory, in neural circuits is one of the most essential concerns in modern neuroscience. Working memory system is often desired to be robust against noises. Such systems can be highly flexible for adapting environmental demands. How neural circuits reconfigure themselves according to the cognitive task requirement remains unclear. Previous studies explored the robustness and the flexibility in working memory by tracing individual dynamical trajectories in a limited time scale, where the accuracy of the results depends on the volume of the collected statistical data. Inspired by thermodynamics and statistical mechanics in physical systems, we developed a non-equilibrium landscape

SUBMITTER: Yan H 

PROVIDER: S-EPMC7531819 | biostudies-literature | 2020 Oct

REPOSITORIES: biostudies-literature