Sarilumab use in severe SARS-CoV-2 pneumonia.

ABSTRACT:

Background

Interleukin-6 signal blockade showed preliminary beneficial effects in treating inflammatory response against SARS-CoV-2 leading to severe respiratory distress. Herein we describe the outcomes of off-label intravenous use of Sarilumab in severe SARS-CoV-2-related pneumonia.

Methods

53 patients with SARS-CoV-2 severe pneumonia received intravenous Sarilumab; pulmonary function improvement or Intensive Care Unit (ICU) admission rate in medical wards, live discharge rate in ICU treated patients and safety profile were recorded. Sarilumab 400 mg was administered intravenously on day 1, with eventual additional infusion based on clinical judgement, and patients were followed for at least 14 days, unless previously discharged or dead.

Findings

Of the 53 SARS-CoV-

SUBMITTER: Gremese E 

PROVIDER: S-EPMC7531933 | biostudies-literature | 2020 Oct

REPOSITORIES: biostudies-literature