Induction of Daptomycin Tolerance in Enterococcus faecalis by Fatty Acid Combinations.

ABSTRACT: Enterococcus faecalis is a Gram-positive bacterium that normally exists as an intestinal commensal in humans but is also a leading cause of nosocomial infections. Previous work noted that growth supplementation with serum induced tolerance to membrane-damaging agents, including the antibiotic daptomycin. Specific fatty acids found within serum could independently provide tolerance to daptomycin (protective fatty acids), yet some fatty acids found in serum did not and had negative effects on enterococcal physiology (nonprotective fatty acids). Here, we measured a wide array of physiological responses after supplementation with combinations of protective and nonprotective fatty acids to better understand how serum induces daptomycin tolerance. When cells were supplemented with either nonprot

SUBMITTER: Brewer W 

PROVIDER: S-EPMC7531955 | biostudies-literature | 2020 Oct

REPOSITORIES: biostudies-literature