A dynamic role for dopamine receptors in the control of mammalian spinal networks.

ABSTRACT: Dopamine is well known to regulate movement through the differential control of direct and indirect pathways in the striatum that express D₁ and D₂ receptors respectively. The spinal cord also expresses all dopamine receptors; however, how the specific receptors regulate spinal network output in mammals is poorly understood. We explore the receptor-specific mechanisms that underlie dopaminergic control of spinal network output of neonatal mice during changes in spinal network excitability. During spontaneous activity, which is a characteristic of developing spinal networks operating in a low excitability state, we found that dopamine is primarily inhibitory. We uncover an excitatory D₁-mediated effect of dopamine on motoneurons and network output that also

SUBMITTER: Sharples SA 

PROVIDER: S-EPMC7532218 | biostudies-literature | 2020 Oct

REPOSITORIES: biostudies-literature