Ontology highlight
ABSTRACT:
SUBMITTER: Zhu W
PROVIDER: S-EPMC7532256 | biostudies-literature | 2020 Oct
REPOSITORIES: biostudies-literature
Zhu Wenli W Zhang Yaling Y Wang Zhen Z Fu Ying Y Yan Yaping Y
Neuroscience bulletin 20200612 10
Neuromyelitis optica (NMO)/NMO spectrum disorder (NMOSD) is a chronic, recurrent, antibody-mediated, inflammatory demyelinating disease of the central nervous system, characterized by optic neuritis and transverse myelitis. The binding of NMO-IgG with astrocytic aquaporin-4 (AQP4) functions directly in the pathogenesis of >60% of NMOSD patients, and causes astrocyte loss, secondary inflammatory infiltration, demyelination, and neuron death, potentially leading to paralysis and blindness. Current ...[more]