Observational and Genetic Associations of Body Mass Index and Hepatobiliary Diseases in a Relatively Lean Chinese Population.

ABSTRACT:

Importance

There is some support for the existence of genetic associations between adiposity and certain hepatobiliary diseases in Western populations. However, there is little evidence of such genetic associations in China, where the causes of these diseases may differ from those in Western populations and the mean body mass index (BMI) is much lower.

Objectives

To compare the observational associations of BMI with hepatobiliary diseases and liver biomarkers with the genetic associations between BMI and these factors and to assess whether the genetic associations of BMI with liver diseases differed by hepatitis B virus infection status.

Design, setting, and participants

This cohort study used data from the prospective China Kadoorie Biobank, including 473 938 adults

SUBMITTER: Pang Y 

PROVIDER: S-EPMC7532388 | biostudies-literature | 2020 Oct

REPOSITORIES: biostudies-literature