Bioinformatics Analysis of Genes and Mechanisms in Postherpetic Neuralgia.

ABSTRACT:

Objective

Elderly patients are prone to postherpetic neuralgia (PHN), which may cause anxiety, depression, and sleep disorders and reduce quality of life. As a result, the life quality of patients was seriously reduced. However, the pathogenesis of PHN has not been fully elucidated, and current treatments remain inadequate. Therefore, it is important to explore the molecular mechanism of PHN.

Methods

We analyzed the GSE64345 dataset, which includes gene expression from the ipsilateral dorsal root ganglia (DRG) of PHN model rats. Differentially expressed genes (DEGs) were identified and analyzed by Gene Ontology. Protein-protein interaction (PPI) network was constructed. The miRNA associated with neuropathic pain and inflammation was found in miRNet. Hub genes were identified

SUBMITTER: Qiu Y 

PROVIDER: S-EPMC7532419 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature