Diffusion and perfusion MRI of normal, preeclamptic and growth-restricted mice models reveal clear fetoplacental differences.

ABSTRACT: Diffusion-weighted MRI on rodents could be valuable to evaluate pregnancy-related dysfunctions, particularly in knockout models whose biological nature is well understood. Echo Planar Imaging's sensitivity to motions and to air/water/fat heterogeneities, complicates these studies in the challenging environs of mice abdomens. Recently developed MRI methodologies based on SPatiotemporal ENcoding (SPEN) can overcome these obstacles, and deliver diffusivity maps at ≈150 µm in-plane resolutions. The present study exploits these capabilities to compare the development in wildtype vs vascularly-altered mice. Attention focused on the various placental layers-deciduae, labyrinth, trophoblast, fetal vessels-that the diffusivity maps could resolve. Notable differences were then observed between the p

SUBMITTER: Bao Q 

PROVIDER: S-EPMC7532452 | biostudies-literature | 2020 Oct

REPOSITORIES: biostudies-literature