Non-Mendelian inheritance during inbreeding of Ca_v3.2 and Ca_v2.3 deficient mice.

ABSTRACT: The mating of 77 heterozygous pairs (Ca_v3.2[+|-] x Ca_v3.2[+|-]) revealed a significant deviation of genotype distribution from Mendelian inheritance in weaned pups. The mating of 14 pairs (Ca_v3.2[-|-] female x Ca_v3.2[+|-] male) and 8 pairs (Ca_v3.2[+|-] female x Ca_v3.2[-|-] male) confirmed the significant reduction of deficient homozygous Ca_v3.2[-|-] pups, leading to the conclusion that prenatal lethality may occur, when one or both alleles, encoding the Ca_v3.2T-type Ca²⁺ channel, are missing. Also, the mating of 63 heterozygous pairs (Ca_v2.3[+|-] x Ca_v2.3[+|-]) revealed a significant deviation of genotype distribution from Mendelian inheritance in weaned pups, but only f

SUBMITTER: Alpdogan S 

PROVIDER: S-EPMC7532468 | biostudies-literature | 2020 Oct

REPOSITORIES: biostudies-literature