Identification of the phytobioactive Polygonum cuspidatum as an antiviral source for restricting dengue virus entry.

ABSTRACT: Dengue virus (DENV) is a mosquito-borne pathogen that is becoming a serious global threat, owing to its rising incidence in inter-tropical regions that yield over 50 million annual infections. There are currently no approved antiviral agents for the management of dengue, and recent shortcomings in its immunization called for immediate action to develop effective drugs with prophylactic ability to better manage its infection. In an attempt to discover novel antiviral sources, we identified the medicinal herb Polygonum cuspidatum (PC) as a bioactive botanical material against DENV infectivity. Specifically, the methanolic extract from PC rhizomes (PCME) potently inhibited DENV infection without causing significant cytotoxicity. Further examination on the viral life cycle demonstrated that PC

SUBMITTER: Kuo YT 

PROVIDER: S-EPMC7532532 | biostudies-literature | 2020 Oct

REPOSITORIES: biostudies-literature