Detection of gray matter microstructural changes in Alzheimer's disease continuum using fiber orientation.

ABSTRACT:

Background

This study aimed to investigate feasible gray matter microstructural biomarkers with high sensitivity for early Alzheimer's disease (AD) detection. We propose a diffusion tensor imaging (DTI) measure, "radiality", as an early AD biomarker. It is the dot product of the normal vector of the cortical surface and primary diffusion direction, which reflects the fiber orientation within the cortical column.

Methods

We analyzed neuroimages from the Alzheimer's Disease Neuroimaging Initiative (ADNI) database, including images from 78 cognitively normal (CN), 50 early mild cognitive impairment (EMCI), 34 late mild cognitive impairment (LMCI), and 39 AD patients. We then evaluated the cortical thickness (CTh), mean diffusivity (MD), which are conventional AD magnetic resona

SUBMITTER: Lee P 

PROVIDER: S-EPMC7532608 | biostudies-literature | 2020 Oct

REPOSITORIES: biostudies-literature