β-glucan attenuates cognitive impairment via the gut-brain axis in diet-induced obese mice.

ABSTRACT:

Background

"Western" style dietary patterns are characterized by a high proportion of highly processed foods rich in fat and low in fiber. This diet pattern is associated with a myriad of metabolic dysfunctions, including neuroinflammation and cognitive impairment. β-glucan, the major soluble fiber in oat and barley grains, is fermented in the lower gastrointestinal tract, potentially impacting the microbial ecosystem and thus may improve elements of cognition and brain function via the gut-brain axis. The present study aimed to evaluate the effect of β-glucan on the microbiota gut-brain axis and cognitive function in an obese mouse model induced by a high-fat and fiber-deficient diet (HFFD).

Results

After long-term supplementation for 15 weeks, β-glucan prevented HFFD-induc

SUBMITTER: Shi H 

PROVIDER: S-EPMC7532656 | biostudies-literature | 2020 Oct

REPOSITORIES: biostudies-literature