Targeting positive feedback between BASP1 and EGFR as a therapeutic strategy for lung cancer progression.

ABSTRACT: Rationale: Brain metastasis in patients with lung cancer is life-threatening. However, the molecular mechanism for this catastrophic disease remains elusive, and few druggable targets are available. Therefore, this study aimed to identify and characterize proteins that could be used as therapeutic targets. Methods: Proteomic analyses were conducted to identify differentially expressed membrane proteins between brain metastatic lung cancer cells and primary lung cancer cells. A neuronal growth-associated protein, brain acid soluble protein 1 (BASP1), was chosen for further investigation. The clinical relevance of BASP1 in lung adenocarcinoma was first assessed. Tyrosine kinase activity assays and in vitro and in vivo functional assays were conducted to explore th

SUBMITTER: Lin CC 

PROVIDER: S-EPMC7532684 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature