Glycosylation, ligand binding sites and antigenic variations between membrane glycoprotein of COVID-19 and related coronaviruses.

ABSTRACT: A new coronavirus strain has wreaked havoc on human lives so the WHO was declared as a pandemic since 20th March 2020. The Membrane glycoprotein MP spans the viral envelope and it has a highly conserved glycosylation sequence.

Aim

Our study goal was to find out the N-glycosylation, ligand binding sites, and antigenic variations between COVID-19 and other associated viruses.

Methods

We performed In silico methodologies for serial analysis at both an operational and result/output level is assessed and compared study factors.

Results

We detected high similarity in sequence alignment for >89% between COVID-19 MP and other MP of CoVs. Prediction of N-glycosylation and cytotoxic T-cell epitopes, we identified precisely sites between SARS-CoV-2 MP and Pangolin CoV MP 1

SUBMITTER: Dawood AA 

PROVIDER: S-EPMC7532767 | biostudies-literature | 2021 Jan-Apr

REPOSITORIES: biostudies-literature