The nine ADAMs family members serve as potential biomarkers for immune infiltration in pancreatic adenocarcinoma

ABSTRACT:

Background

The functional significance of ADAMs family members in the immune infiltration of pancreatic adenocarcinoma (PAAD) awaits elucidation.

Methods

ADAMs family members with significant expression were identified among differentially expressed genes of PAAD based on The Cancer Genome Atlas (TCGA) database followed by a verification based on the Oncomine database. The correlation of ADAMs in PAAD was estimated with the Spearman’s rho value. The pathway enrichment of ADAMs was performed by STRING and GSEALite, respectively. The protein–protein interaction and Gene Ontology analyses of ADAMs and their similar genes were exanimated in STRING and visualized by Cytoscape. Subsequently, the Box-Whisker plot was used to show a correlation between ADAMs and different tumor g

SUBMITTER: Qi B 

PROVIDER: S-EPMC7532768 | biostudies-literature | 2020 Jan

REPOSITORIES: biostudies-literature