Meta-analysis of gene expression profiling reveals novel basal gene signatures in MCF-10A cells transformed with cadmium.

ABSTRACT: Cadmium (Cd²⁺) is an environmental toxicant and a human carcinogen. Several studies show an association of Cd²⁺ exposure to the development of breast cancer. Previously, we have transformed the immortalized non-tumorigenic cell line MCF-10A with Cd²⁺ and have demonstrated that the transformed cells have anchorage independent growth. In a separate study, we showed that transformation of the immortalized urothelial cells with the environmental carcinogen arsenite (As³⁺) results in an increase in expression of genes associated with the basal subtype of bladder cancer. In this study, we determined if transformation of the MCF-10A cells with Cd²⁺ would have a similar effect on the expression of basal genes. The results of our study indicate

SUBMITTER: Blommel K 

PROVIDER: S-EPMC7533076 | biostudies-literature | 2020 Sep

REPOSITORIES: biostudies-literature