Temporal integration of narrative information in a hippocampal amnesic patient.

ABSTRACT: Default network regions appear to integrate information over time windows of 30 ​s or more during narrative listening. Does this long-timescale capability require the hippocampus? Amnesic behavior suggests that regions other than the hippocampus can independently support some online processing when input is continuous and semantically rich: amnesics can participate in conversations and tell stories spanning minutes, and when tested immediately on recently heard prose they are able to retain some information. We hypothesized that default network regions can integrate the semantically coherent information of a narrative across long time windows, even in the absence of an intact hippocampus. To test this prediction, we measured BOLD activity in the brain of a hippocampal amnesic patient (D.A.

SUBMITTER: Zuo X 

PROVIDER: S-EPMC7533077 | biostudies-literature | 2020 Jun

REPOSITORIES: biostudies-literature