Genetic Testing for BCHE Variants Identifies Patients at Risk of Prolonged Neuromuscular Blockade in Response to Succinylcholine.

ABSTRACT:

Background

Genetic variants in the BCHE (butyrylcholinesterase) gene are associated with reduced BChE enzyme activity and prolonged post-succinylcholine neuromuscular blockade, which can lead to postanesthetic apnea and respiratory depression. Testing for BChE deficiency is usually performed by biochemical methods and is generally only offered to patients who have a personal or family history of prolonged post-succinylcholine neuromuscular blockade.

Purpose

Using a clinical test, we investigated the frequencies of BCHE genotypes that are associated with increased risk for prolonged post-succinylcholine neuromuscular blockade.

Materials and methods

Five BCHE variants, including the A (atypical, rs1799807), K (Kalow, rs1803274), F₁ (fluor

SUBMITTER: Zhu GD 

PROVIDER: S-EPMC7533272 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature