Empirical Comparison and Analysis of Web-Based DNA N ⁴-Methylcytosine Site Prediction Tools.

ABSTRACT: DNA N ⁴-methylcytosine (4mC) is a crucial epigenetic modification involved in various biological processes. Accurate genome-wide identification of these sites is critical for improving our understanding of their biological functions and mechanisms. As experimental methods for 4mC identification are tedious, expensive, and labor-intensive, several machine learning-based approaches have been developed for genome-wide detection of such sites in multiple species. However, the predictions projected by these tools are difficult to quantify and compare. To date, no systematic performance comparison of 4mC tools has been reported. The aim of this study was to compare and critically evaluate 12 publicly available 4mC site prediction tools according to species specificity, based on

SUBMITTER: Manavalan B 

PROVIDER: S-EPMC7533314 | biostudies-literature | 2020 Dec

REPOSITORIES: biostudies-literature