Electron availability in CO₂ , CO and H₂ mixtures constrains flux distribution, energy management and product formation in Clostridium ljungdahlii.

ABSTRACT: Acetogens such as Clostridium ljungdahlii can play a crucial role reducing the human CO₂ footprint by converting industrial emissions containing CO₂ , CO and H₂ into valuable products such as organic acids or alcohols. The quantitative understanding of cellular metabolism is a prerequisite to exploit the bacterial endowments and to fine-tune the cells by applying metabolic engineering tools. Studying the three gas mixtures CO₂  + H₂ , CO and CO + CO₂  + H₂ (syngas) by continuously gassed batch cultivation experiments and applying flux balance analysis, we identified CO as the preferred carbon and electron source for growth and producing alcohols. However, the total yield of moles of carbon (mol-C) per electrons co

SUBMITTER: Hermann M 

PROVIDER: S-EPMC7533319 | biostudies-literature | 2020 Nov

REPOSITORIES: biostudies-literature