Clinical predictors and explant lung pathology of acute exacerbation of idiopathic pulmonary fibrosis.

ABSTRACT: Idiopathic pulmonary fibrosis (IPF) is characterised by constant threat of acute exacerbation of IPF (AE-IPF). It would be significant to identify risk factors of AE-IPF. We sought to determine the prognostic value of lung transplantation candidacy testing for AE-IPF and describe explant pathology of recipients with and without AE-IPF before lung transplantation. Retrospective cohort study of 89 IPF patients listed for lung transplantation. Data included pulmonary function testing, echocardiography, right heart catheterisation, imaging, oesophageal pH/manometry and blood tests. Explanted tissue was evaluated by pulmonary pathologists and correlated to computed tomography (CT) findings. Out of 89 patients with IPF, 52 were transplanted during stable IPF and 37 had AE-IPF before transplantat

SUBMITTER: Dotan Y 

PROVIDER: S-EPMC7533375 | biostudies-literature | 2020 Oct

REPOSITORIES: biostudies-literature