The changes of immune-related molecules within the ileal mucosa of piglets infected with porcine circovirus type 2.

ABSTRACT:

Background

Enteritis is one of the most frequently reported symptoms in piglets infected with porcine circovirus type 2 (PCV2), but the immunopathogenesis has not been reported.

Objectives

This study examined the effect of a PCV2 infection on the intestinal mucosal immune function through morphological observations and immune-related molecular detection.

Methods

Morphological changes within the ileum of piglets during a PCV2 infection were observed. The expression of the related-molecules was analyzed using a gene chip. The immunocyte subsets were analyzed by flow cytometry. The secretory immunoglobulin A (SIgA) content was analyzed by enzyme-linked immunosorbent assay.

Results

The PCV2 infection caused ileal villus damage, intestinal epithelial cells exfoliati

SUBMITTER: Shi F 

PROVIDER: S-EPMC7533395 | biostudies-literature | 2020 Sep

REPOSITORIES: biostudies-literature