Uncovering potential differentially expressed miRNAs and targeted mRNAs in myocardial infarction based on integrating analysis.

ABSTRACT: Myocardial infarction (MI) is one of the leading causes of death globally. The aim of the present study was to find valuable microRNAs (miRNAs/miRs) and target mRNAs in order to contribute to our understanding of the pathology of MI. miRNA and mRNA data were downloaded for differential expression analysis. Then, a regulatory network between miRNAs and mRNAs was established, followed by function annotation of target mRNAs. Thirdly, prognosis and diagnostic analysis of differentially methylated target mRNAs were performed. Finally, an in vitro experiment was used to validate the expression of selected miRNAs and target mRNAs. A total of 19 differentially expressed miRNAs and 1,007 differentially expressed mRNAs were identified. Several regulatory interaction pairs between miRNA and mRNAs wer

SUBMITTER: Wang S 

PROVIDER: S-EPMC7533449 | biostudies-literature | 2020 Nov

REPOSITORIES: biostudies-literature