CRISPR/Cas9: A powerful genome editing technique for the treatment of cancer cells with present challenges and future directions.

ABSTRACT: Cancer is one of the most leading causes of death and a major public health problem, universally. According to accumulated data, annually, approximately 8.5 million people died because of the lethality of cancer. Recently, a novel RNA domain-containing endonuclease-based genome engineering technology, namely the clustered regularly interspaced short palindromic repeat (CRISPR)-associated protein-9 (Cas9) have been proved as a powerful technique in the treatment of cancer cells due to its multifunctional properties including high specificity, accuracy, time reducing and cost-effective strategies with minimum off-target effects. The present review investigates the overview of recent studies on the newly developed genome-editing strategy, CRISPR/Cas9, as an excellent pre-clinical therapeutic

SUBMITTER: Hazafa A 

PROVIDER: S-EPMC7533657 | biostudies-literature | 2020 Dec

REPOSITORIES: biostudies-literature