Anticholinergics May Carry Significant Cognitive and Gait Burden in Parkinson's Disease.

ABSTRACT:

Background

Anticholinergic drugs are associated with significant cognitive and other adverse events in older adults, including those with Parkinson's disease (PD). Anticholinergic effects are considered lesser in younger individuals and the burden and outcomes in younger patients with PD are unknown.

Objectives

To determine the cumulative anticholinergic burden in a cohort of younger of patients with PD and to correlate the same with cognitive impairment and freezing of gait (FOG).

Methods

We conducted a cross-sectional study to identify the cumulative anticholinergic burden from medications prescribed to patients with PD. Two standard scales, the Anticholinergic Cognitive Burden (ACB) scale and the ACB score, were used to calculate the anticholinergic burden from pre

SUBMITTER: Rajan R 

PROVIDER: S-EPMC7533974 | biostudies-literature | 2020 Oct

REPOSITORIES: biostudies-literature