Order versus disorder in two isomorphous pyrazolone-substituted diethyl propane-dioates prepared using a three-component one-pot reaction under solvent-free conditions.

ABSTRACT: Two new substituted propane-dioate esters have been synthesized using a three-component solvent-free thermal reaction between diethyl propane-dioate (diethyl malonate), 5-chloro-3-methyl-1-phenyl-1H-pyrazole-4-carbaldehyde and an aryl azide, forming two new C-C bonds in a single step. The products diethyl (RS)-2-[(4-bromo-phen-yl)(5-methyl-3-oxo-2-phenyl-2,3-di-hydro-1H-pyrazol-4-yl)meth-yl]propane-dioate, C₂₄H₂₅BrN₂O₅ (I), and diethyl (RS)-2-[(4-chloro-phen-yl)(5-methyl-3-oxo-2-phenyl-2,3-di-hydro-1H-pyrazol-4-yl)meth-yl]propane-dioate, C₂₄H₂₅ClN₂O₅ (II), are isomorphous, with Z' = 2 in space group P2₁/n. The two independent mol-ecules

SUBMITTER: Shreekanth TK 

PROVIDER: S-EPMC7534245 | biostudies-literature | 2020 Oct

REPOSITORIES: biostudies-literature