Two types of colistin heteroresistance in Acinetobacter baumannii isolates.

ABSTRACT: In this study, we investigated the colistin heteroresistance patterns in Acinetobacter baumannii isolates. To identify colistin heteroresistance, population analysis profiling was performed for six in vitro colistin-susceptible A. baumannii isolates. Survival rates with and without prior exposure to colistin (at concentrations between 0 and 32 mg/L) were measured in media with and without colistin. Amino acid substitutions were also detected in colonies that survived in media with 4 mg/L colistin without further antibiotic treatment in six A. baumannii isolates. A stability test was also performed to investigate whether colistin resistance is maintained without antibiotic treatment. Although only three isolates showed typical colistin heteroresistance pattern, c

SUBMITTER: Hong YK 

PROVIDER: S-EPMC7534296 | biostudies-literature | 2020 Dec

REPOSITORIES: biostudies-literature