MyD88-mediated TLR signaling protects against acute rotavirus infection while inflammasome cytokines direct Ab response.

ABSTRACT: Rotavirus (RV) infects small intestinal epithelial cells, inducing severe diarrhea in children, resulting in over 500,000 deaths annually. Relatively little is known about how innate immunity contains acute infection and drives adaptive immune responses that afford complete clearance of RV and protection against future infection. Hence, we examined the consequence of the absence of MyD88, known to be central to innate immunity, in a mouse model of RV infection. The absence of MyD88, but not combined blockade of IL-1β and IL-18 signaling, resulted in greater infectivity, as reflected by levels of RV in feces, intestinal lysates and viremia. Such increased RV levels correlated with an increase in incidence and duration of diarrhea. Loss of MyD88 also impaired humoral immunity to RV. Specific

SUBMITTER: Uchiyama R 

PROVIDER: S-EPMC7534410 | biostudies-literature | 2015 May

REPOSITORIES: biostudies-literature