Renal Function is a Major Determinant of ICU-acquired Hypernatremia: A Balance Study on Sodium Handling.

ABSTRACT:

Background and objectives

The development of ICU-acquired hypernatremia (IAH) is almost exclusively attributed to 'too much salt and too little water'. However, intrinsic mechanisms also have been suggested to play a role. To identify the determinants of IAH, we designed a prospective controlled study.

Methods

Patients with an anticipated length of stay ICU > 48 hours were included. Patients with hypernatremia on admission and/or on renal replacement therapy were excluded. Patients without IAH were compared with patients with borderline hypernatremia (≥ 143 mmol/L, IAH 143) and more severe hypernatremia (≥ 145 mmol/L, IAH 145).

Results

We included 89 patients, of which 51% developed IAH 143 and 29% IAH 145. Sodium intake was high in all patients. Fluid balances were s

SUBMITTER: van IJzendoorn M 

PROVIDER: S-EPMC7534501 | biostudies-literature | 2020 Sep

REPOSITORIES: biostudies-literature