SARS-CoV-2 Infection Dysregulates the Metabolomic and Lipidomic Profiles of Serum.

ABSTRACT: COVID-19 is a systemic infection that exerts significant impact on the metabolism. Yet, there is little information on how SARS-CoV-2 affects metabolism. Using NMR spectroscopy, we measured the metabolomic and lipidomic serum profile from 263 (training cohort) + 135 (validation cohort) symptomatic patients hospitalized after positive PCR testing for SARS-CoV-2 infection. We also established the profiles of 280 persons collected before the coronavirus pandemic started. Principal-component analysis discriminated both cohorts, highlighting the impact that the infection has on overall metabolism. The lipidomic analysis unraveled a pathogenic redistribution of the lipoprotein particle size and composition to increase the atherosclerotic risk. In turn, metabolomic analysis reveals abnormally hig

SUBMITTER: Bruzzone C 

PROVIDER: S-EPMC7534591 | biostudies-literature | 2020 Oct

REPOSITORIES: biostudies-literature