Epstein-Barr virus-derived circular RNA LMP2A induces stemness in EBV-associated gastric cancer.

ABSTRACT: Cancer stem cells (CSCs) are cancer-initiating cells that are not only a source of tumorigenesis but also the cause of tumour progression, metastasis and therapy resistance. EBV-associated gastric cancer (EBVaGC) is a distinct subtype of gastric cancer with unique clinicopathological and molecular features. However, whether CSCs exist in EBVaGC, and the tumorigenic mechanism of EBV, remains unclear. Here, NOD/SCID mice were injected subcutaneously with the EBVaGC cell line SNU719 and treated with 5-fluorouracil weekly. Successive generations of xenografts yielded a highly malignant EBVaGC cell line, SNU-4th, which displays properties of CSCs and mainly consists of CD44⁺ CD24^- cells. In SNU-4th cells, an EBV-encoded circRNA, ebv-circLMP2A, expression increased and play

SUBMITTER: Gong LP 

PROVIDER: S-EPMC7534631 | biostudies-literature | 2020 Oct

REPOSITORIES: biostudies-literature