Decreased complement C3 levels are associated with poor prognosis in patients with COVID-19: A retrospective cohort study.

ABSTRACT:

Objectives

To describe the humoral immune feature of patients with coronavirus disease 2019 (COVID-19).

Methods

The levels of total immunoglobulins (IgG, IgM, IgA, and IgE), complement (C3, C4) results were retrospectively analyzed in COVID-19 patients. Univariable and multivariable logistic regression were performed to explore the risk factors associated with the in-hospital death.

Result

A total of 236 patients were enrolled in this study, of which 169 were transferred to another institution or discharged (survival group) and 67 died in hospital (non-survival group). Compared with survivors, the levels of IgA and IgE in non-survivors increased significantly, and level of complement C3 decreased. Non-survivors also showed higher incidence of chest tightness, breath s

SUBMITTER: Fang S 

PROVIDER: S-EPMC7534659 | biostudies-literature | 2020 Dec

REPOSITORIES: biostudies-literature